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Beta-lactamase & media plates

EUCODIS Bioscience manufactures and delivers “LacBuster™”, EUCODIS Bioscience's pure and high-performing beta-lactamases. LacBuster™ has been optimized for sterility testing and environmental monitoring in the manufacture and dosage formulation of beta-lactam antibiotics and for specific diagnostic purposes.

LacBuster™-L is a novel sterile ready-to-use solution. Due to its high performance LacBusterTM-L is especially well suited for the direct inoculation method and membrane filtration tests according to US Pharmacopeia (USP <71>) and EP. It can be directly implemented into existing standard operating procedures.

LacBuster™-S is a novel beta-lactamase formulation with a broad substrate range against beta-lactam antibiotics including all clinically relevant carbapenems, cephalosporins up to 5th generation and penicillins. LacBuster™ addresses the needs of leading antibiotics manufacturers and laboratories interested in sterility testing of biological specimens and shows a significantly higher efficacy than other products currently in the market.

Penase is a penicillinase with a specific substrate range solely against all relevant penicillins. Penase is available as a freeze-dried powder.

EUCODIS beta-lactamases offer:

  • Broad substrate range
  • GMP-compliant formulation (LacBuster-LTM)
  • Long stability >1 year

Sterility Tests

Product Catalogue Formulation Sales Unit Enzymatic Activity (IU/VIAL)





Beta-Lactamase I

Beta-Lactamase II

LacBuster-L EB008.1 sterile liquid (10 ml) GMP 10 2 500 1 000
LacBuster-S EB006.1 sterile freeze-dried powder gamma irradiated 10 500 50
LacBuster-S EB006.2 sterile freeze-dried powder gamma irradiated 1 20 000 2 000
LacBuster-S EB006.4 freeze-dried powder non-irradiated 1 50 000 5 000
Penase EB002.1 freeze-dried powder 1 3 300 -

Find out more

For price inquiries, please contact our sales team under
sales(at)eucodis.com  >

LacBuster™ agar plates for environmental monitoring

EUCODIS Bioscience provides a general purpose growth medium supplemented with LacBuster™ to effectively neutralize beta-lactam antibiotics. The media plates are suitable for the cultivation of a wide variety of microorganisms in environmental monitoring within the pharmaceutical industry. We offer contact and settle plates for high performance monitoring of your isolators and clean rooms during beta-lactam manufacture.

Why use LacBuster™ media plates?

  • High enzymatic activity of 1 000 IU/L cephalosporinase and 10 000 IU/L penase
  • Suitable for all commonly used disinfectants
  • H2O2-impermeable triple-sleeve packaging
  • Gamma-irradiated (20 – 35 kGy)
  • Long shelf life: 7 months
  • Convenient storage at room temperature

Environmental Monitoring

Product Formulation Sales Unit Enzymatic Activity (IU/L)




Beta-Lactamase I

Beta-Lactamase II

LacBuster - settle plates agar plates gamma irradiated 10 10 000 1 000
LacBuster - contact plates agar plates gamma irradiated 10 10 000 1 000
LacBuster-S for production of own agar plates bulk    


All enzymes are also available in bulk quantities; please inquire at our sales team.

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